Areas of Scientific Interest
Human population genomics; Sports genetics; Kinesiogenomics; Obesity genomics; Genomics in gerontology and biology of healthy aging; Genetic causes of preterm newborns; Translational genomics; functional genomics; Bioinformatic analysis; Annotation; Artificial intelligence.
Main Activities / Research Directions
Human Population Genomics
- Study of genetic differences between populations.
- Genome diversity and evolutionary adaptation studies.
- Studies on the origin and migration of populations.
- Elucidation of natural selection mechanisms and their impact on human populations.
Genetics of physical performance and sports genomics
- Genetic studies of human physical performance.
- Kinesiogenomics and the molecular basis of physical activity.
- Genome and phenome studies of high-performance athletes.
Translational Genomics
- Obesity genetics and genomics – research on genetic factors influencing metabolism and metabolic response to physical exercise. Randomized intervention studies.
- Longevity genomics and biology of healthy aging – genome, epigenome, and phenome studies of gerontological issues.
- In-depth phenotypic and genotypic assessment of preterm and full-term newborns and their mothers.
Bioinformatic Analysis Algorithms
- Research on genome analysis processes and data standardization.
- Improvement of bioinformatic analysis and annotation algorithms using artificial intelligence.
Competencies
- Genome, epigenome, and phenome research.
- Gene network and interactome research.
- Functional molecular biology research.
- Bioinformatic analysis algorithms, annotation.
Research
- Prevention of Obesity: Molecular Analysis of Biomarkers and Their Signaling Pathways and Their Significance for Personalized Treatment.
- Analysis of De Novo Variants and Their Significance for Genomic Adaptive Fitness in a Cohort of Premature Infants in Lithuania.
- Prognostic and Predictive Biomarkers of Physical Performance in Athletes: The First Steps Towards Precision Sports Medicine.
- Study of the Application of Standardization Principles for Genome Annotation Developed by the Global Alliance for Genome Health (GA4GH) in Lithuania.
- Improvement of Genome Annotation Algorithms to Create Annotations Based on Nucleosome Distribution Profiles Around Active Genomic Elements. Research and Comparison of Nucleosome Sequence Profiles Under Various Conditions and in Different Populations.
- Verification of the Existence of Positive Selection for 48 SNP Variants Associated with Sarcopenia.
- Study of the Application of Artificial Intelligence Text Analysis Algorithms in Genome Annotation.
- Colorectal Cancer. Research focuses on the gut microbiome of patients with colorectal cancer through the analysis of stool samples. Microbial DNA is extracted from patient stool samples, and microbiota composition is characterized using 16S rRNA gene sequencing on the Oxford Nanopore Technologies (ONT) platform. The research is conducted in collaboration with scientists from the North Estonia Medical Centre Foundation (Estonia).
Doctoral Students
Investigation of the Effects of Microplastics and Genetic Factors on Preterm Birth and Maternal–Fetal Health. Duration: 2025–2029. PhD Student: Lina Lisauskienė Supervisor: Assoc. Prof. Dr. Alina Urnikytė.
Group Leader
Assoc. Prof. Dr. Alina Urnikytė is an Associate Professor at the Faculty of Medicine, Vilnius University, a Senior Researcher, and Head of the Population Genomics Laboratory. She has been a member of the Vilnius University academic community since 2009, dedicating her research to human genomics, from uncovering the genetic history of human populations to developing innovative approaches for personalized medicine.
She obtained her Bachelor's degree in Biotechnology from the University of Vic (Spain) and earned her PhD in Medicine at Vilnius University in 2018 with a dissertation focused on the genetic origins and population history of Lithuanians. In 2023, she completed a postdoctoral research project entitled "The Impact of Natural Selection on Infectious Diseases in the Lithuanian Population."
Her research interests include human population genomics, epigenomics, translational genomics, and the discovery of biomarkers for complex diseases and pregnancy-related complications. Under her leadership, the Population Genomics Laboratory applies advanced genomic, epigenomic, transcriptomic, and microbiome research technologies to better understand the molecular mechanisms of disease, identify novel biomarkers, and contribute to the development of early diagnostic and personalized medicine approaches. In addition to fundamental research on human evolution and population genomics, the laboratory conducts studies on pregnancy complications, congenital heart defects, obesity, sports genomics, and other areas of biomedical research.
International research experience has played an important role in shaping her scientific career and leadership. She has undertaken research visits at Pompeu Fabra University (Spain), the Latvian Biomedical Research and Study Centre, the University of Szczecin (Poland), the University of Pisa (Italy), and the University of Coimbra (Portugal), fostering international collaborations and expanding expertise in advanced genomic technologies.
Assoc. Prof. Dr. Alina Urnikytė is actively involved in teaching, supervising undergraduate, master's and doctoral students, and promoting science to the wider public. She believes that the most meaningful scientific discoveries emerge where trust, respect, shared purpose, and strong teamwork inspire people to create lasting value for society.
Methods and Infrastructure Used
Genomics and Epigenomics Platforms
Illumina iScan System
- Genome-wide genotyping (SNP microarrays)
- DNA methylation (epigenome) analysis using Illumina Infinium EPIC and other array-based platforms
Oxford Nanopore Technologies (ONT) Platform
- Whole-genome sequencing (WGS)
- RNA sequencing (RNA-seq)
- 16S rRNA gene sequencing for microbiome analysis
- Shotgun metagenomic sequencing
- Native DNA methylation analysis
Molecular Biology Methods
Quantitative Real-Time PCR (qPCR)
- Telomere length measurement
- Genotyping of selected genetic variants
Bioinformatics and Data Analysis
- High-performance computing infrastructure
- Bioinformatic analysis of genomic, epigenomic, transcriptomic, and microbiome datasets
- Statistical analysis, machine learning, and artificial intelligence methods for biological data analysis
Experimental Facilities
- Vivarium for preclinical research
Projects (National, International, and with Private Entities)
- Genomic, Epigenomic, and Telomere Length Characteristics in Sarcopenia and Age-Related Frailty. Project No. LMT. Contract No. S-MIP-22-36.
- Functional Studies of Human Genes Associated with Spontaneous Preterm Birth Using the Danio rerio Model System. Project No. MSF-JM-18/2023. Funded by the Vilnius University Research Promotion Fund.
- Prognostic and Predictive Biomarkers in Sports: A Large-Scale Genome-Wide Association Study in Elite Athletes. Project No. MSF-JM-08/2024. Funded by the Vilnius University Research Promotion Fund.
- “Impact of Multi-system Precision Investigation in Left-sided Heart Lesions (IMPULSE)” - is an international research project funded under the ERA4Health – InterHeart 2025 call, "Fostering a European Research Area for Health." The project is supported by the Research Council of Lithuania (RCL/LMT) through the ERA4Health Partnership (Grant Agreement No. 101095426) under the European Union's Horizon Europe Research and Innovation Programme. Project duration: 2026–2029. Principal Investigator: Assoc. Prof. Dr. Skaistė Sendžikaitė. Key Researchers: Assoc. Prof. Dr. Alina Urnikytė, Dr. Laura Pranckėnienė, and MD Svetlana Dauengauer-Kirlienė.
Cooperation and Partnerships
- Vilnius University Hospital Santaros Clinics, Neonatology Department, Lithuania.
- Vilnius University Hospital Santaros Clinics, Children's Hospital, Lithuania.
- Nature Research Centre, Laboratory of Eukaryote Engineering, Lithuania.
- Vilnius University, Faculty of Philology, Department of Baltic Studies, Lithuania.
- Vilnius University, Faculty of Medicine, Institute of Translational Health Research, Center for Human Bioarchaeology and Paleogenetics, Lithuania.
- Latvian Biomedical Research and Study Centre, Riga, Latvia.
- University of Szczecin, Institute of Biology, Department of Genetics and Genomics, Poland.
- March 11th Lyceum, Puńsk, Poland.
- Department of Medical Sciences and Public Health, University of Cagliari, Italy.
- Juntendo University, Japan.
- Gdansk University of Physical Education and Sport, Gdańsk, Poland.
- The London Health Sciences Centre Research Institute (750 Base Line Road East, London, Ontario, Canada).
Events
THE FUTURE OF SPORTS SCIENCE – an annual international scientific and practical conference focused on recent developments in sports science, physical activity, health, and sports medicine. The conference brings together researchers, sports and healthcare professionals, coaches, students, and members of the academic community from Lithuania and abroad, supporting closer links between science and practice and building international partnerships. Main Organizer: Assoc. Prof. Dr. Valentina Ginevičienė.
“DNA Summer” Educational Programme for School Students – a week-long educational programme held annually at the Institute of Translational Health Research, Faculty of Medicine, Vilnius University. It is designed for students in Grades 5–8 from across Lithuania. During the programme, participants gain hands-on experience in genetics, genomics, molecular biology, and biomedical research methods, visit research laboratories, carry out practical experiments, and take part in interactive science activities. The programme aims to encourage interest in life sciences, introduce students to modern biomedical research, and inspire them to consider a future career in science. Main Organizer: Assoc. Prof. Dr. Alina Urnikytė.
List of Employees and Contacts
Dr. Alina Urnikytė (Head of Laboratory)
E-mail:
Dr. Valentina Ginevičienė
E-mail:
Dr. Laura Pranckėnienė
E-mail:
Dr. Erinija Pranckevičienė
E-mail:
Acad. Prof. Habil. Dr. Vaidutis Kučinskas
E-mail:
PhD student Austėja Letukienė
E-mail:
PhD student Gabija Anikevičiūtė
E-mail:
Information for Those Interested in Cooperation
Cooperation and Services: large-scale genome and epigenome (DNA methylation profile) studies; Telomere length determination by real-time PCR and assessment; Genetic profile assessment of athletes; Pedigree determination and assessment; DNA isolation; Comprehensive bioinformative annotation of genetic variants.
Keywords: quantitative PCR; telomeres; epigenome; methylation; genetic profiling; bioinformative annotation.
For cooperation and partnerships at the Translational Health Research Institute, please contact: